Expertise in Analytics

Integral BioSystems has niche expertise in complex characterization techniques for small molecules, peptides, proteins and nucleic acids. Contact us to discuss your project.

HPLC/ UPLC Based Method Development and Transfer

  • Assay/ RS
  • Stress Degradation
  • Impurity Mapping
    i. Small Molecules
    ii. Proteins
    iii. Peptides
    iv. Nucleic Acids

Detectors Available (HPLC) for Drug Quantitation

  • Electrochemical
  • Refractive Index
  • UV-Vis
  • Evaporative Light Scattering

ICH Stability Studies of Drug Products

Size Exclusion Chromatography

  • MW, Polydispersity index
    Aggregation by SEC
  • Quantitation of polymers and
  • biopolymers

LC/MS/MS

  • R&D Bioanalytical Assay in Ocular
    Tissues

GC

  • Volatile analysis in Drug product matrices

Determination of Critical Micellar
Concentration (CMC)

Ex-Vivo Corneal Permeability Studies

  • Franz Cell Diffusion Studies
  • Drug Content in Cornea
  • Kinetics of Drug Permeation

ELISA

  • Protein Quantitation

Determination of Log P

Microscopy

  • Polarized Light Microscopy
  • Scanning Electron Microscopy
  • Transmission Electron Microscopy

XRPD

  • Polymorph
  • Crystalline Habit/Pole Densities

Polymorph Screening

  • Recrystallizations
  • Annealing
  • Solvent Effects

Thermal Characterization

  • DSC/TGA

Osmometry and pH

Conductivity

Rheology

  • Shear studies
  • Temperature studies
  • Aqueous and Organic Solvent-based
    Viscosities

Surface Tension

Interfacial Tension

Contact Angle

Peel Strength/Young’s Modulus

Thickness Measurement

Zeta Potential

Particle Size Analysis by Laser Light
Diffraction

Karl Fisher

hpcl

XRPD of nanocrystals of a commercial ophthalmic suspension

lc-ms

Calculated pole-figures for the [001], [100], [020] and
[110] crystallographic axes for an ophthalmic suspension

invitro

In-vitro release of a 39-amino acid peptide
from a sustained release matrix

thermal-characterization

Liquid Crystalline Order of a Peptide in Aqueous
Solution: Assessment by Polarized Light Microscopy

surface-tension

SolGel Transition of a Peptide in Water, as a
Function of Temperature

CRO Services for Analytics

Integral BioSystems is a contract research organization that provides quality services specializing in pre clinical stage pharmaceutical research and development at a competitive price and turnaround time. Our commitment to excellence shines through in every aspect of our services, ensuring unparalleled precision and reliability in your research and development endeavors. Learn more about our CRO services >

Ready to unlock the full potential of your research with cutting-edge characterization techniques? Contact Integral BioSystems today to harness the power of our expertise and elevate your projects to new heights. Let’s embark on a journey of scientific discovery together!