Picture courtesy: Nature Reviews, Drug Discovery
Drugs administered orally are typically absorbed through the following transport mechanisms: (a) transcellular, where the drug is absorbed through the epithelial cells, (b) paracellular, where the drug is absorbed through the tight junctions of the epithelium, (c) transcytosis or receptor-mediated endocytosis and (d) absorption through the Peyer’s patches.
Integral BioSystems designs oral delivery systems to enhance the bioavailability of drugs by enhancing the absorption, protecting drugs from the corrosive, acidic environment of the stomach fluids by encapsulating the drugs and delivering to a specific site in the gastro-intestinal tract.
We specialize in self-emulsifying delivery systems (SDDS), fast release tablets, gels and capsules, micronized forms, microencapsulates and sustained release dosage forms.
Once some prototype delivery systems are designed and tested for in-vitro release, permeability through intestinal membranes can be studied through measurement of diffusion of the drug, as a function of the formulation. We have extensive oral dosage form testing apparatus in our laboratories.
|
