Ophthalmic Drug Delivery

Integral BioSystems has 50+ years of combined experience in ophthalmic drug delivery and is one of the few premier contract research organizations in this field.

A significant challenge to the ocular drug delivery scientists is the necessity to circumvent the protective barriers of the eye without tissue damage. The goal of ophthalmic drug delivery is the design of therapeutic systems that will achieve optimal concentrations of the selected drug at the target tissue, for an appropriate duration.

Ocular disposition and elimination of a therapeutic agent is dependent upon its physico-chemical properties as well as the relevant ocular anatomy and physiology.  As much as 95% of the total volume of the ophthalmic solution is lost by drainage into the lacrimal duct, tear turnover and conjunctival absorption. Thus, for acceptable bioavalability, a proper duration of contact with the cornea must be maintained.

Factors that are important in the design of ophthalmic delivery systems are intrinsic permeability of the drug through the various ocular tissues such as cornea, sclera, etc., biocompatibility of the delivery system with ocular tissues and the ability of the delivery system to “deliver” a predictable concentration of drug over the desired time duration. 

anatomy of the eye

CRO Services for Ophthalmic Drug Delivery

Types of Ophthalmic Formulations

These dose forms can be developed fee-for-service for our clients.  

  • Suspensions
  • Solutions
  • Injectables-Sustained Release
  • Microspheres
  • Depot formulations

Capabilities ​

  • Expert Guidance
  • Method Transfer/Method Development
  • Development of Target Product Profile
  • Compatibility Studies with excipients
  • Prototype Fabrication and characterization
  • Permeability Studies of drug through Corneal and Scleral Tissues
  • In-Vitro Compatibility Studies of the drug with ocular tissues
  • In-Vitro release experiments 
  • Stability studies of the ocular formulation
  • Container closure compatibility
  • Scale up and tech transfer
woman applying eyedrops

Facilities & Equipment

23 Crosby Drive,
Suite 100A,
Bedford, MA 01730

50+ Years of Combined Experience

Our scientific staff operate with the highest standards of integrity, quality, excellence, and safety with the ultimate goal of doing good science.

CEO Shikha Barman, PhD has 27 years of experience in drug development with numerous patents and publications in drug delivery, biomaterials and gene delivery. She was inducted as a Fellow in 2021 from AIMBE for her contributions to drug delivery. Dr Barman’s background spans ophthalmic, injectable (IM), dermal (sublingual and targeted therapies). She was featured in C&EN, ACS in April, 2013 issue as one of four women entrepreneurs to watch, and a Technology Showcase winner in 2015 in CRO/CMO, Boston, MA.

COO and Company IP Attorney Dave Karasic is Integral’s first investor. He brings 35 years of engineering, IP and legal experience to the company.

founders

Why Choose Integral BioSystems

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Some of our amazing customers

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What Our Clients Say

Integral has provided outstanding support in formulation evaluation and development, always taking into account the particulars of our drug candidate, stage of development, and target indications.
Henry Hsu
MD, CEO, Allysta Pharmaceuticals, CA
They are very approachable and creative to bring you solutions with complete candor on what can or cannot be achieved. They also work with you to ensure that your timelines and budget needs are met.
Sevgi Gurkan
MD, Founder and CEO, Perfuse Therapeutics, CA
Integral has provided outstanding support in formulation evaluation and development, always taking into account the particulars of our drug candidate, stage of development, and target indications.
Bruce Cao
Director, CMC, FHI 360 Jennifer Ayres, Director, Pharmaceutical Development, FHI 360

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